※ 引述《lingon (風往哪裡去)》之銘言： : Monoclonal antibody is the first generation of HIV vaccine, and : it has failed so far, and it is expected to fail in the foreseen : future. The primary challenge of using monoclonal antibody : against HIV is two folds. First antibody can only target : the coating proteins of free virus, which limits the number of : proteins and sites antibody can target. Secondly, the two : env proteins, gp41 and gp120, are highly variable such that : HIV can easily mutate at antibody binding site (epitopes) : and thus escape monoclonal antibody targeting. : These are the two primary reasons why a lot of people have : given up on making a monoclonal antibody based vaccine. : for reference, Jay Berzofsky, AJ McMichael, Bruce Walker, and : Rowland-Jones are good names to look up. 可以請問一下嗎?我以前有個想法 既然HIV無法治療的主要原因,是因為他突變的太快了 那有沒有可能在治療上 我們先施與能 induce HIV RNA repair protein 的compound 使他在replication時,修補能力增加,減少mutation機會 再配合其它療法予以治療? 謝謝... : ※ 引述《[email protected] (想找個人真心來疼)》之銘言： : : 現在已經有發展單株抗體用來對抗HIV嗎? : : 成效又是如何? : : 遇到的瓶頸又是怎樣? : : 有沒有什麼比較大的缺點 : : 懇請大家可以給點答案或資訊 : : 謝謝^^~ --

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