※ 引述《lingon (风往哪里去)》之铭言： : Monoclonal antibody is the first generation of HIV vaccine, and : it has failed so far, and it is expected to fail in the foreseen : future. The primary challenge of using monoclonal antibody : against HIV is two folds. First antibody can only target : the coating proteins of free virus, which limits the number of : proteins and sites antibody can target. Secondly, the two : env proteins, gp41 and gp120, are highly variable such that : HIV can easily mutate at antibody binding site (epitopes) : and thus escape monoclonal antibody targeting. : These are the two primary reasons why a lot of people have : given up on making a monoclonal antibody based vaccine. : for reference, Jay Berzofsky, AJ McMichael, Bruce Walker, and : Rowland-Jones are good names to look up. 可以请问一下吗?我以前有个想法 既然HIV无法治疗的主要原因,是因为他突变的太快了 那有没有可能在治疗上 我们先施与能 induce HIV RNA repair protein 的compound 使他在replication时,修补能力增加,减少mutation机会 再配合其它疗法予以治疗? 谢谢... : ※ 引述《[email protected] (想找个人真心来疼)》之铭言： : : 现在已经有发展单株抗体用来对抗HIV吗? : : 成效又是如何? : : 遇到的瓶颈又是怎样? : : 有没有什麽比较大的缺点 : : 恳请大家可以给点答案或资讯 : : 谢谢^^~ --

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