【问题】：Sickle cell disease (SCD) is found in numerous populations whose ancestral homes are in the malaria belt of Africa and Asia. SCD is an autosomal recessive disorder that results from homozygosity for a mutant β-globin gene allele. Data on one affected population indicates that approximately 4 in 100 newborn infants have SCD. Epidemiologic data on the population in the previous problem reveal that before the application of modern medical treatment, natural selection played a major role in shaping the frequencies of alleles. Heterozygous individuals have the highest relative fitness; and in comparison to heterozygotes, those who are βAβA have a relative fitness of 91 percent, but only about 25 percent of those with SCD survived to reproduce. What is the estimated equilibrium frequency of βA in this population? What is the estimated equilibrium frequency of βS in this population? 【问题起因】：mastering genetics 【个人看法】： q^2=0.25-->q=0.5 ( βS in this population) 2pq=0.91-->p=0.91/2*0.5 (βA in this population) 答案是错的 有人知道怎们做吗?谢谢 --

※ 发信站: 批踢踢实业坊(ptt.cc), 来自: 99.25.204.89 ※ 文章网址: http://webptt.com/cn.aspx?n=bbs/Biology/M.1416064448.A.E5C.html