From: http://news.sina.com.tw/global/sinacn/cn/2007-02-23/16493472351.shtml 日本利用活细菌长期保存资料 北京新浪网 (2007-02-23 16:49) 　　新华网东京2月23日电 日本庆应大学一个研究小组最近开发出一种可长期保存资 料的新技术：利用活细菌替代磁片和光盘等存储媒介，从而将资料保存数百年甚至数 千年时间。 　　据日本《朝日新闻》21日报导，生物用以保存遗传资讯的ＤＮＡ其实也是一种记 忆媒介。通过基因重组技术，人们可将人为资料记录在某些生物的ＤＮＡ上。不过， 由於ＤＮＡ在上一代传给下一代的过程中可能发生序列变化，它所保存的资料容易发 生缺损。 　　研究小组在枯草菌ＤＮＡ的4个地方用不同方式保存了相同内容的资料，以便在 其ＤＮＡ序列发生变化和破损的情况下，仍能使资料被复原。电脑演示结果表明，即 使细菌『更新换代』，资料仍可保存数百年甚至数千年。 　　研究小组说，这项利用细菌存储资料的技术比光盘或硬盘更适合长期保存资料。 朝日新闻 连结 生きた细菌にデータを保存　庆应などのチームが开发 (日文) http://www.asahi.com/national/update/0221/TKY200702210105.html 日经新闻 连结 バクテリアを记录媒体に？　庆大が技术 (日文) http://www.nikkei.co.jp/news/main/20070220AT1G2002Z20022007.html 原始论文： http://pubs.acs.org/cgi-bin/abstract.cgi/bipret/asap/abs/bp060261y.html Biotechnol. Prog., ASAP Article 10.1021/bp060261y S8756-7938(06)00261-X Web Release Date: January 25, 2007 Copyright (c) 2007 American Chemical Society and American Institute of Chemical Engineers Alignment-Based Approach for Durable Data Storage into Living Organisms Nozomu Yachie, Kazuhide Sekiyama, Junichi Sugahara, Yoshiaki Ohashi,* and Masaru Tomita Institute for Advanced Biosciences, Keio University, 403-1 Nipponkoku, Daihoji, Tsuruoka, 997-0017 Yamagata, Japan; Bioinformatics Program, Graduate School of Media and Governance, Keio University, 5322 Endo, Fujisawa, 252-8520 Kanagawa, Japan; Department of Environmental Information, Keio University, 5322 Endo, Fujisawa, 252-8520 Kanagawa, Japan; and Human Metabolome Technologies, Inc., 246-2 Mizukami, Kakuganji, Tsuruoka, 997-0052 Yamagata, Japan Received August 28, 2006. Accepted December 18, 2006. Abstract: The practical realization of DNA data storage is a major scientific goal. Here we introduce a simple, flexible, and robust data storage and retrieval method based on sequence alignment of the genomic DNA of living organisms. Duplicated data encoded by different oligonucleotide sequences was inserted redundantly into multiple loci of the Bacillus subtilis genome. Multiple alignment of the bit data sequences decoded by B. subtilis genome sequences enabled the retrieval of stable and compact data without the need for template DNA, parity checks, or error-correcting algorithms. Combined with the computational simulation of data retrieval from mutated message DNA, a practical use of this alignment-based method is discussed. --

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