※ 引述《tiniwiel (tiniwiel)》之铭言： : ※ 引述《peter3752001 (手黑的脚白佑)》之铭言： : : 读季玮珠老师的那份讲义 : : 有些问题 : : 请知道的同学或路过的学长姐 : : 帮忙解惑吧 : : 卫导不好念,但是要普救世人 : : 就要咬牙撑过去啊~~~(感冒中,喉咙痛) : : 1.P.2中间左边那张ppt : : literature retrieval and exclusion criteria是什麽意思? : : 2.P.4中间右边那张"基本设计"的对照组 : : 下面写说跟个案对照方法的对照不同 : : 是哪里不同? : : : 3.同上页右下 依照时间 : : 同时是怎麽对照? : : 历史又是怎麽对照? : 我在网路上找到的资料...可以参考一下啦 : 虽然是英文的 但我觉得他解释得满清楚的 : historical control: : The results of treatment with the test drug : are compared with experience historically derived from the adequately : documented natural history of the disease or condition, or from the : results of active treatment, in comparable patients or populations. : Because historical control populations usually cannot be as well : assessed with respect to pertinent variables as can concurrent control : populations, historical control designs are usually reserved for special : circumstances. Examples include studies of diseases with high and : predictable mortality (for example, certain malignancies) and studies in : which the effect of the drug is self-evident (general anesthetics, drug : metabolism). : : 4.P.5左下 : : 纳入跟排除条件在说什麽? : Inclusion and exclusion criteria are a means of establishing precision : in your cohort or case-control study. For example, you might suspect that : a new brand of insulin tablet is more effective than an existing brand, : but for some reason this seems to be true only for diabetic patients that : are not overweight by more than 10%. Your professional knowledge has : produced a "hunch" that has you well on your way to establishing inclusion : and exclusion criteria. : Inclusion criteria are the criteria for including a patient in the study, : and it is important that these criteria be clearly defined in an objective : manner, so that anyone involved in the study (or anyone attempting to : replicate the study) can reproduce patient inclusion decisions precisely. : In other words, can you write down the inclusion criteria so that anyone else : with professional knowledge similar to your own would include the same patients : you included? : The example above, of the new insulin tablet versus an existing one, could be : translated into an inclusion criteria by specifying the two drugs (e.g. brand : name, generic and manufacturer name, possibly even lot number). : Exclusion criteria are the criteria for excluding patients from the study. : From the example above, the 10% overweight criterion could serve as the basis : for a specific exclusion criteria statement. As in the case of inclusion : criteria, is your specification precise enough that someone with knowledge : similar to your own would exclude the same patients you choose to exclude? : : 5.P.6右上 : : 事件是最终的终点 : : 二分法则是叫硬性终点 : : 所以事件不等於硬性终点吧(是二分法才是)? : : 6.同上张 : : 设限资料跟存活分析是什麽? : : (虽然不会考这麽细,但是可不可以稍微讲一下) 存活分析:事件/事件史资料(二分法 硬性终点)加上时间轴 就成为存活分析了吧 : : 7.Basic approaches是在讲什麽的方法? 囧 : : 8.P.7右上 : : 何谓干扰因素? : : 为什麽说结果比流行病学研究可信? : : (那现在说的是什麽方法在跟流行病学研究比?) : : 9.同上页中间左边那张 : : 为什麽加入时间就变存活分析? 应该就可以画曲线图表示 在某一时间点个体的生死吧(此处的硬性终点应该是存活/死亡) : : 10.同上页左下 : : Marginal是什麽意思? : : 11.P.8右上 : : 非标准实验方法又称准实验方法??? : : 12.P.9 : : 实验方法有很多种而药物临床试验只是其中一种,对吗? : : 实验方法等不等於实验流行病学? 请向阿汤哥借"公共卫生学" 今天看了里面有实验流病学的解释喔 : : 问题颇多发现自己好像读太细了~ : : 捉不到重点啊~ : 你真的读的很细！！让我发现自己很多地方都没看清楚... : 呵呵～大家加油！！ 问题 第二页左上outcomes in outcome management 是啥意思捏 --

※ 发信站: 批踢踢实业坊(ptt.cc) ◆ From: 59.117.1.200