作者chromosome (桃园画家)
看板medstudent
标题[申覆] 医学一 (53)
时间Mon Feb 21 21:38:31 2011
医学一 53题 答案:C 申覆:ABCD
Kramer-Hämmerle S,HIV type 1 Nef promotes neoplastic transformation of
immortalized neural cells.S Res Hum Retroviruses. 2001 May 1;17(7):597-602.
These in vivo data suggest that Nef promotes neoplastic transformation of
immortalized murine neural stem cells and enhances malignancy of
low-tumorigenic human astrocytoma cells. Nef may therefore be involved
in the development of AIDS-associated brain tumors.
重点是有很多人目前在做HIV-nef 对 malignant transformation的研究，比如
Lehmann MH, HIV-1 Nef upregulates CCL2/MCP-1 expression in astrocytes in a
myristoylation- and calmodulin-dependent manner.
J Cell Sci. 2006 Nov 1;119(Pt 21):4520-30. Epub 2006 Oct 17.
还有
Robichaud GA, Poulin L.HIV type 1 nef gene inhibits tumor necrosis factor
alpha-induced apoptosis and promotes cell proliferation through the action
of MAPK and JNK in human glial cells.AIDS Res Hum Retroviruses. 2000
Dec 10;16(18):1959-65.
这题问的是何者跟transformation无关，看这种研究结果应该不能说HIV-nef无关吧
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1F：→ SilverVine:journal的资料申覆要过很困难吧 02/21 21:50
2F：→ SilverVine:医学(二) 71 跟这题也满像的 都是期刊找得到 02/21 21:57
3F：推 flamingcat:可以丢看看啦 不过真的要看审核者是不是有佛心@@ 02/22 00:45